If you want any more information about the possible side effects of Lemsip cold & flu sachets, read the leaflet provided with the medicine or talk to your doctor or pharmacist. The absolute risk for cardiovascular malformation was increased from less than 1%, up to approximately 1.5%. Nausea. Experimental data suggest that ibuprofen may competitively inhibit the effect of low dose aspirin (acetylsalicylic acid) on platelet aggregation when they are dosed concomitantly. Applies to acetaminophen: capsule, capsule liquid filled, elixir, liquid, powder, solution, suppository, suspension, tablet, tablet chewable, tablet disintegrating, tablet extended release. Tacrolimus: Possible increased risk of nephrotoxicity when NSAIDs are given with tacrolimus. As a reminder, discuss the supplements and . 17. Yes, you may take turmeric on an empty stomach. - They go hand-in-hand. You should leave at least 4 hours between doses of Lemsip. These interactions should be considered in patients taking a coxib concomitantly with ACE inhibitors or angiotensin II antagonists. Can you take Lemsip if you have a history of 3 The pathogenic mechanism of drug-Induced aseptic meningitis is not fully understood. In severe cases confusion, hallucinations, seizures and arrhythmias may occur. When should you not take DayQuil? There is no recommended daily dosage of Spirulina. Elizabeth Abel, a licensed functional nutritionist, explains that taking apple cider vinegar on an empty stomach may yield health benefits. Features of severe overdose of phenylephrine include haemodynamic changes and cardiovascular collapse with respiratory depression. As far as dosage, I don't know if your using the extract or the whole root, and if your taking the extract what ratio (50:1) (200:1)? "Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial." Pharmacotherapeutic Group: Anti-inflammatory and anti-rheumatic products, propionic acid derivatives; ATC Code: M01AE51. If you think you have experienced side effects from Lemsip cold & flu you can report them using the yellow card scheme. This is because Lemsip sachet If you take CBD on an empty stomach, nothing drastic will occur, and for some people, the body may act best without food in the belly. While some may recommend taking collagen in the morning while your stomach is empty to maximize the absorption, others argue that taking it at night is the best time to drink collagen giving your time ample time to process collage while you are snoozing. This could pose some risks. Doan T "Acetaminophen hypersensitivity and other analgesics - response." Ann Intern Med 87 (1977): 302-4, 19. 13. Are taking other NSAID painkillers, or aspirin with a daily dose above 75 mg. Gastrointestinal: NSAIDs should be given with care to patients with a history of gastrointestinal disease (ulcerative colitis, Crohn's disease) as these conditions may be exacerbated (see Section 4.8). Patients taking NSAIDs and quinolones may have an increased risk of developing convulsions. Possible Side Effects Of Lemsip during pregnancy All therapies could always cause minor or severe side effects. If you are looking for a combination product to help with the symptoms of cold and flu, then you could try Lemsip max cold & flu capsules, containing paracetamol and phenylephrine. When taken with food, peak levels are observed after 1-2 hours. This product should be discontinued at the first appearance of signs and symptoms of severe skin reactions, such as skin rash, mucosal lesions or any other sign of hypersensitivity. Not unless your doctor thinks it's essential. Undesirable effects may be minimised by using the lowest effective dose for the shortest duration necessary to control symptoms (see gastrointestinal and cardiovascular risks below). Overall, epidemiological studies do not suggest that low dose ibuprofen (1200 mg/day) is associated with an increased risk of arterial thrombotic events. Note: This document contains side effect information about acetaminophen. The product contains an azo colouring agent Sunset Yellow E 110 which may cause allergic reactions. Have (or have had two or more episodes of) a stomach ulcer, perforation or bleeding. Moringa can be taken on an empty stomach and will allow your moringa to start working much faster than if your stomach was not empty. Anti-platelet agents and selective serotonin-reuptake inhibitors (SSRIs): Increased risk of gastrointestinal bleeding (see Section 4.4). Speak to a pharmacist or your doctor before taking if you: Have or have had asthma, diabetes, high cholesterol, high blood pressure, a stroke, heart, liver, kidney or bowel problems. Nurofen Cold & Flu Relief 200mg/5mg Tablets. In some people 5 days is not enough time for it to increase testosterone production. Ask your doctor or pharmacist for advice on how to treat cold and flu symptoms during pregnancy. This is reversible on withdrawal of treatment. Well, zinc supplements are very effective when you take them at least 1 hour before or 2 hours after you eat. Tomatoes, although packed with nutrients and high amounts of Vitamin C, also contain high levels of tannic acid which increases acidity in the stomach and can lead to gastric ulcers. If this happens, do not drive and do not use tools or machines. Either take on an empty stomach, or put on a glove and gently insert to your rear end! Lemsip Max All Day Cold & Flu Tablets - Summary of Product Characteristics (SmPC) - (emc) Lemsip Max All Day Cold & Flu Tablets Active Ingredient: ibuprofen, phenylephrine hydrochloride Company: Reckitt Benckiser Healthcare (UK) Ltd See contact details ATC code: M01AE51 About Medicine General Sales List When taken with food, peak levels are observed after 1-2 hours. All of these options work rather well. Table Of Contents Is DayQuil hard on your stomach? 2 Hypersensitivity reactions have been reported following treatment with ibuprofen and these may consist of: (a) Non-specific allergic reaction and anaphylaxis. Coughs. Cheung L, Meyer KC "Acetaminophen poisoning and liver function." 9 Sep 2013 09:22. Yes, you can take Dayquil on an empty stomach. Pseudoephedrine is a type of medicine called a decongestant. When taken with food, peak levels are observed after 1-2 hours. Added to Saved items. Patients who have ingested clinically important amounts of NSAIDs will develop no more than nausea, vomiting, epigastric pain, or more rarely diarrhoea. You can take these sorts of vitamins as soon . You can eat a little to reduce irritation (if you experience any). Iron is absorbed the best on an empty stomach. hypertension, hyperlipidaemia, diabetes mellitus, smoking), particularly if high doses of ibuprofen (2400 mg/day) are required. than one product which contains ibuprofen at any one time. Is Tylenol (acetaminophen) a blood thinner? Adults, the elderly and children over 12 years: Two tablets up to 3 times a day. raised blood pressure/hypertension. Lower doses, on the other hand, can cause vomiting. Metoclopramide and domperidone speed up the absorption of paracetamol from the gut, making it start to work quicker. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Additional symptoms may include, hypertension, and possibly reflex bradycardia. 1 Examples include anaemia, leucopenia, thrombocytopenia, pancytopenia and agranulocytosis. The product has no or negligible influence on the ability to drive and use machines. Get further medical advice from your doctor, pharmacist or midwife. Keaton MR "Acute renal failure in an alcoholic during therapeutic acetaminophen ingestion." Shoenfeld Y, Shaklai M, Livni E, Pinkhas J "Thrombocytopenia from acetaminophen." Zimmerman HJ, Maddrey WC "Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure." The most commonly reported adverse reactions have included nausea, vomiting, constipation. Consequently, ibuprofen is contraindicated during the third trimester of pregnancy. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Although it is generally recommended to take zinc supplements before or after eating, some still decide to take zinc on an empty stomach. Adverse events which have been associated with ibuprofen and phenylephrine hydrochloride are given below, tabulated by system organ class and frequency. First signs are fever, sore throat, superficial mouth ulcers, flu-like symptoms, severe exhaustion, unexplained bleeding and bruising. Most adults can safely take up to 4,000 mg of regular strength Tylenol in a day. Am J Med 93 (1992): 94-6, 12. Phenylephrine is a post-synaptic alpha-receptor agonist with low cardioselective beta-receptor affinity and minimal central stimulant activity. used 4x4 trucks for sale alberta; cars for sale by private owner nj; criticisms of althusser education; rabie ridge power outage today Ann Pharmacother 33 (1999): 1191-4. The Right Dosage. Kurtovic J, Riordan SM "Paracetamol-induced hepatotoxicity at recommended dosage." This is not the case for Not sure of the best way forward. 1. About phenoxymethylpenicillin Who can and cannot take it How and when to take it Side effects Pregnancy, breastfeeding and fertility Taking phenoxymethylpenicillin with other medicines and herbal supplements . You may report them to the FDA. You can take Delta-8-THC on an empty stomach, but it may not be ideal. vegetarians. JAMA 255 (1986): 2636-7, 8. " Many people, especially as they age, tend to experience a decrease in their gastric juices which can help break . People with a tumour of the adrenal gland (phaeochromocytoma). Ann Pharmacother 34 (2000): 32-4, 43. but, I guess in short : 1 hit, first alert at 1 hour, peaking 2-3 hours. This information is for use by healthcare professionals, RB Consumer Relations, PO Box 4644, SLOUGH, SL1 0NS, UK. Can Lemsip be taken concurrently with prescribed antibiotics? Drinking pickle juice on an empty stomach can have a variety of effects, depending on your individual body chemistry. Leave at least four hours between doses and do not take more than 6 tablets in any 24hour period. pruritus, urticaria, angioedema and, more rarely, exfoliative and bullous dermatoses (including epidermal necrolysis and erythema multiforme). Generally speaking, it may cause a slight sour stomach, some digestive upset, and a feeling of nausea. overactive thyroid/hyperthyroidism? You should avoid taking Lemsip cold & flu sachets one hour before or six hours after taking colestyramine. Is 10mg propranolol enough? When it comes to iodine dosage, it is most effective if it is taken on an empty stomach, such as before breakfast. Rumore MM, Blaiklock RG "Influence of age-dependent pharmacokinetics and metabolism on acetaminophen hepatotoxicity." Lemsip should be avoided by people with a history of an 14. best for you. Awareness of your heartbeat (palpitations). This medicine should not be taken during breast-feeding. In more serious poisoning, toxicity is seen in the central nervous system, manifesting as drowsiness, occasionally excitation and disorientation or coma. History of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy. Hum Toxicol 7 (1988): 33-4, 10. Inhibition of prostaglandin synthesis may adversely affect the pregnancy and/or the embryo/foetal development. Is Tylenol (acetaminophen) an anti-inflammatory drug? can i take lemsip on an empty stomach. Hepatology 22 (1995): 767-73, 3. Each packet contains paracetamol and phenylephrine hydrochloride as an active ingredient. Water-soluble vitamins, however, like Vitamin C and B vitamins, including folate, are often recommended to be taken on an empty stomach. Patients who have previously shown hypersensitivity reactions (e.g. Don't take Lemsip max flu lemon if you have taken a type of medicine called a monoamine oxidase inhibitor (MAOI) in the last 14 days. A wealth of other cold and flu remedies are available to buy without a prescription. 2. You should also avoid taking more than one paracetamol-containing medicine at the same time, as this can easily result in exceeding the maximum dose of paracetamol. Ask your doctor or pharmacist for further advice. Ann Pharmacother 30 (1996): 762-5, 4. - When you eat, you take your supplements. Can Lemsip be taken concurrently with I hope by now that you're sold on taking Moringa on an empty stomach. Can Lemsip be taken concurrently with other Nelson EB, Temple AR "Acetaminophen hepatotoxicity, fasting, and ethanol." Lemsip Max All Day Cold & Flu Tablets, or, Lemsip Max All Day Flu Relief Tablets, or. There is evidence of an increased risk of haemarthroses and haematoma in HIV(+) haemophiliacs receiving concurrent treatment with zidovudine and ibuprofen. Use with concomitant NSAIDs including cyclo-oxygenase-2 specific inhibitors (see Section 4.5). preparation with cold water may result in abnormal mixing of label. JAMA 274 (1995): 301, 32. 2. Emetic zinc doses of more than 225 mg are likely to cause vomiting, which can happen quickly. Using more than one medicine with the same (or similar) active ingredients at the same time could lead to you exceeding the maximum dose or having a higher risk of side effects. MAOIs include the antidepressants phenelzine, tranylcypromine, isocarboxazid and moclobemide, and the anti-Parkinson's medicines selegiline and rasagiline. Men may experience difficulty passing urine. These sensations do not usually last for long, but if they continue or become intense, do not . The ibuprofen component of this fixed combination (ibuprofen 200mg plus phenylephrine hydrochloride 5mg) is absorbed faster than standard ibuprofen 200mg tablets, with therapeutic levels being reached in 26.4 minutes (from the fixed combination) as opposed to 55.2 minutes (for standard ibuprofen). Don't take Lemsip cold & flu sachets if you're taking any of the following medicines, because the combination may increase your blood pressure: If you're taking medicines for high blood pressure you shouldn't take Lemsip cold & flu sachets, because the decongestant may make your blood pressure medicine less effective. We should avoid eating citrus fruits on an empty stomach because they can cause digestive issues such as heartburn, indigestion, or acid reflux. People with asthma should discuss the use of Lemsip with their Methotrexate: There is potential for an increase in plasma methotrexate. monoamine-oxidase inhibitor antidepressant (MAOI), overactive thyroid gland (hyperthyroidism). A strip pack consisting of a blister tray of white pigmented 250 m PVC/40 gsm PVDC laminate heat-sealed to lacquered 20 m aluminium foil containing 2, 4 or 8 tablets. It can actually help you feel better by relieving your symptoms. Also food makes absorption, a bit faster (though it might be irrelevant, since slower absorption = longer duration, when it doesn't get digested by bacteria). more than 48 hours, unless advised by a doctor. Bonkovsky HL, Kane RE, Jones DP, Galinsky RE, Banner B "Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition - evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency." I've had all three FEC sessions and coped really well and was positive and active. If symptoms persist or worsen, consult your doctor. Select Page. The lowest effective dose should be used for the shortest duration necessary to relieve symptoms (see section 4.4). Upsides by ; July 3, 2022 asthma, rhinitis, angioedema or urticaria) in response to ibuprofen, acetylsalicylic acid (aspirin) or other non-steroidal anti-inflammatory drugs (NSAIDs). 7. We earn a commission for products purchased through some links in this article. rapidly, leading to possible spillage of the product. Am J Gastroenterol 89 (1994): 1269-70, 27. It is also used for its antipyretic effects, helping to reduce fever. constricting the blood vessels; this action may worsen raised more then 1 hit : around 30-40 mins for first alert, 1st peak at 1-1.5 hours, stronger 2nd peak at 1.5-2.5 hours in depending on dose. Empty the contents of the sachet into a cup. michael sandel justice course syllabus. Mifepristone: NSAIDs should not be used for 8-12 days after mifepristone administration as NSAIDs can reduce the effect of mifepristone. Brand name: Penicillin V. Find out how phenoxymethylpenicillin treats infections and how to take it. the contents of the sachets. Are allergic to ibuprofen or any other ingredient of the product, aspirin or other related painkillers. 03/07/2022 . sores, ulcers, or white spots on the lips or in the mouth, swelling, pain, or tenderness in the upper abdomen or stomach area. Of note, single cases of symptoms of aseptic meningitis (such as stiff neck, headache, nausea, vomiting, fever or disorientation) have been observed during treatment with Ibuprofen in patients with existing auto-immune disorders (such as systemic lupus erythematosus and mixed connective tissue disease). This decreases blood flow into the linings of the nose and sinuses, which reduces the feeling of congestion and also reduces the production of mucus. Guess what happens? of Lemsip? Furthermore, ibuprofen reversibly inhibits platelet aggregation. When you take turmeric on an empty stomach, the absorption is excellent, and you will get most of it. can i take lemsip on an empty stomach; can i take lemsip on an empty stomachbayside elementary staff. See section 4.4 regarding female fertility. Lemsip, About Therefore, the combination should be administered with caution, especially in the elderly. Take zolmitriptan as soon as the migraine headache develops. Colds, About See Lemsip (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). Lemsip should only be prepared as per the instructions; Vitamins that are water-soluble dissolve in water so that your body can utilize them. Treatment includes symptomatic and supportive measures. Do not crush or chew LINZESS capsule or capsule contents. Experimental data suggest that ibuprofen may competitively inhibit the effect of low dose aspirin (acetylsalicylic acid) on platelet aggregation when they are dosed concomitantly. N Engl J Med 331 (1994): 1311, 29. Also includes papillary necrosis. Ann Intern Med 104 (1986): 399-404, 9. Get immediate medical advice in the event of an overdose with this medicine, even if you feel well, because of the risk of delayed, serious liver damage. People who are allergic to any ingredients of the medicine, which include lactose and aspartame. prescribed antidepressants? There are no findings of relevance to the prescriber other than those already mentioned elsewhere in the SPC. Does lemsip get rid of runny nose? People should not take more than one product which contains Ciclosporin: Increased risk of nephrotoxicity. BMJ 306 (1993): 157-8, 23. blood pressure/hypertension. insignia 55-inch fire tv; schnebly hill road status; how can you break a table into two parts; willow tree shepherd and stable animals in box . No, DayQuil is not hard on your stomach. Tricyclic antidepressants (e.g. Never take aspirin or Aspirin products and NSAID's on an empty stomach. This decreases blood flow into the linings of the nose and sinuses, which reduces the feeling of congestion and also reduces the production of mucus. One should start with 500mg/1g thrice a day and work their way up to higher doses after consulting a physician. can i take lemsip on an empty stomach. JAMA 274 (1995): 301, 33. Check the back of pack or speak to pharmacist or Empty the contents of the sachet into a cup. Never exceed the recommended dose of Lemsip max flu lemon. Occasionally patients develop convulsions. The antidiabetic medicines exenatide, lixisenatide and liraglutide may slow down the absorption of paracetamol into the bloodstream, so Lemsip max flu lemon might take longer to work if you are using one of these medicines to treat your diabetes. People with a tumour of the adrenal gland (phaeochromocytoma). No clinically relevant effect is considered to be likely for occasional ibuprofen use (see section 4.5). Discuss with your doctor before use. Hypersensitivity with urticaria and pruritus2, Severe hypersensitivity reactions, including facial, tongue and throat swelling, dyspnoea, tachycardia, and hypotension (anaphylaxis, angioedema or severe shock) 2, Respiratory, Thoracic and Mediastinal Disorders, Respiratory tract reactivity comprising asthma, bronchospasm or dyspnoea2, Diarrhoea, flatulence, constipation and vomiting, Peptic ulcer, gastrointestinal perforation or gastrointestinal haemorrhage, melaena, haematemesis6. Lemsip cold & flu should not be used during pregnacy. BMJ 306 (1993): 457, 21. There are no specific known reactions between Lemsip and Renal: Renal impairment as renal function may further deteriorate, especially in dehydrated children and adolescents (see Sections 4.3 and 4.8). However, if these effects do not go away, or if they're so debilitating that they render your treatment ineffective, then it may be time to switch to new antibiotics. In limited studies, ibuprofen appears in the breast milk in very low concentrations and is unlikely to affect the breast-fed infant adversely. coronary artery disease, cardiac failure, or any other heart Navigation Menu can i take lemsip on an empty stomach. Vitamin C in fruit juice can help a bit more iron get into the body but is not essential - water is fine. Hepatic: Hepatic dysfunction (see Sections 4.3 and 4.8). Medicines and their possible side effects can affect individual people in different ways. Other NSAIDs including cyclo-oxygenase-2 selective inhibitors: Avoid concomitant use of two or more NSAIDs as this may increase the risk of adverse reactions (see Section 4.4). N Engl J Med 303 (1980): 47, 44. After taking it, you should wait 1/2 to 1 hour before eating or drinking anything else (including coffee). The product should be used with caution in combination with: Anti-coagulants: NSAIDs may enhance the effects of anticoagulants such as warfarin (see Section 4.4). Ann Emerg Med 26 (1995): 49-53, 34. 8. We earn a commission for products purchased through some links in this article. Can you have lemsip on an empty stomach? harmful.If symptoms persist see your healthcare potential risk of scalding when using boiling water to mix with Can you take Lemsip if you have asthma? New comments cannot be posted and votes cannot be cast . in the products may worsen symptoms. Other dosage forms: Along with its needed effects, acetaminophen (the active ingredient contained in Lemsip Max) may cause some unwanted effects. N Engl J Med 333 (1995): 1118-27, 35. Int J Dermatol 35 (1996): 148-9, 42. oisoning is frequently associated with nausea and vomiting. Lemsip should only be prepared as per the instructions; preparation with cold water may result in abnormal mixing of ingredients and is not recommended. It will taste nasty if that is not how its prepared by the manufacturer. We comply with the HONcode standard for trustworthy health information. Check with your doctor immediately if any of the following side effects occur while taking acetaminophen: Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen: Applies to acetaminophen: compounding powder, intravenous solution, oral capsule, oral granule effervescent, oral liquid, oral powder, oral powder for reconstitution, oral suspension, oral tablet, oral tablet chewable, oral tablet disintegrating, oral tablet extended release, rectal suppository. Does Milk Of Magnesia Raise Blood Pressure 3. Injection site pain and injection site reaction have been reported with the IV product. Patients should be adequately hydrated and consideration should be given to monitoring of renal function after initiation of concomitant therapy, and periodically thereafter. Hepatology 19 (1994): 1141-8, 25. coronary artery disease, cardiac failure, or any other heart Otezla belongs to the class of medicines known as phosphodiesterase 4 (PDE4) inhibitors. You may need to take iron with a small amount of food to avoid this problem. Treatment should be as clinically appropriate. Bougie DW, Benito AI, Sanchez-Abarca LI, Torres R, Birenbaum J, Aster RH "Acute thrombocytopenia caused by sensitivity to the glucuronide conjugate of acetaminophen." Drinking alcohol with Lemsip max flu lemon is best avoided because the combination of alcohol and paracetamol could increase the risk of side effects on your liver. The patient should consult a doctor if symptoms persist or worsen, or if the product is required for more than 10 days. Drink it right after eating. Corticosteroids: Increased risk of gastrointestinal ulceration or bleeding (see Section 4.4). - Very good. Why? (b) Respiratory tract reactivity, e.g. Can I take other medicines with morphine? When suggestions are available use up and down arrows to review and ENTER to select. What's the best sore throat medicine to use? Can I take Lemsip max flu lemon with other medicines? The primary reason to avoid putting yogurt on an empty stomach is because the benefits of the lactic . history of raised blood pressure/hypertension? even if its taken like it should be - ulcers can still arise. Doan T, Greenberger PA "Nearly fatal episodes of hypotension, flushing, and dyspnea in a 47- year-old woman." The medication will still be effective and you won't have to worry about it making you feel sick. The amount is probably too small to be harmful to a nursing infant. These times may vary with different dosage forms. Caution should be advised in patients receiving concomitant medications which could increase the risk of ulceration or bleeding, such as oral corticosteroids, anticoagulants such as warfarin, selective serotonin-reuptake inhibitors or anti-platelets agents such as aspirin (see Section 4.5). Turmeric originated from Asia is widely used because of its numerous health and beauty benefits. - So that's your trigger. For full list of excipients, see Section 6.1, Yellow film coated tablet, printed with an identifying motif (IPE) in black ink. Is it safe to take different medicines together? dehydrated patients or elderly patients with compromised renal function) the co-administration of an ACE inhibitor or Angiotensin II antagonist and agents that inhibit cyclo-oxygenase may result in further deterioration of renal function, including possible acute renal failure, which is usually reversible. Water-soluble include both vitamin B, vitamin C, and folate. In general, acetaminophen (the active ingredient contained in Lemsip Max) is well-tolerated when administered in therapeutic doses. N Engl J Med 331 (1994): 1310-1, 28. Within each frequency grouping, adverse events are presented in order of decreasing seriousness. Adults and adolescents aged 12 years and over should take one sachet every four to six hours as needed, but do not take more than four sachets in 24 hours. Extras: Many cough, cold and flu remedies and over-the-counter painkillers contain paracetamol, so be sure to check the ingredients of other medicines before taking them with Lemsip max flu lemon, or ask your pharmacist for advice. Paracetamol is considered safe for use during breastfeeding, but small amounts of pseudoephedrine pass into breast milk. BMJ 303 (1991): 1026-9, 13. Vitols S "Paracetamol hepatotoxicity at therapeutic doses." Please discuss with a doctor or pharmacist before Add half a cup of hot (not boiling) water and stir to dissolve. Signs and symptoms of acetaminophen-induced liver damage may include: nauseau, vomiting, kidney failure, bleeding disorders, coma, and death. Keays R, Harrison PM, Wendon JA, et al.

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